Royal Air Force Typhoon jets have conducted a mission with France's air force in a combined operation targeting an underground arms cache in Syrian territory operated by the IS group, as stated by the British defence ministry.
The facility, located using intelligence, was assessed as housing weapons and explosive materials, the statement said, and was positioned in hills just to the north of the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed Paveway IV guided bombs to target a several entry passages down to the facility... initial indications are that the objective was successfully hit," the MoD said.
There was no sign of any civilian casualties in the operation late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager tanker plane.
Daesh - alternatively referred to as ISIS - established extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike shows our UK leadership, and commitment to stand shoulder to shoulder with our partners, to eliminate any resurgence of the terrorist group and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed patrols over Syrian airspace to "forestall any attempted comeback" of IS subsequent to its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to the personnel of our armed forces who took part in this strike for their expertise and their valour," Healey said. "Including them were a great many British personnel stationed over the holidays. This mission, to take out militants who threaten our security, demonstrates how UK forces are prepared to act, all year round, keeping Britain secure domestically and powerful internationally."
During December, the United States armed forces executed what it called a "massive strike" on IS targets in Syria, following an ambush killed two US servicemembers and a civilian linguist in the Palmyra area.
The UN estimates Islamic State still maintains roughly 5-7 thousand fighters in both countries.